› 8rxh

Electron Microscopy
2.93Å resolution

CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN

Released:
DOI: 10.2210/pdb8rxh/pdb
PDB entry 8rxh coloured by chain, front view.
PDB entry 8rxh coloured by chain, side view.
PDB entry 8rxh coloured by chain, top view.
Source organism: Leishmania major strain Friedlin
Primary publication:
Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Rajan KS, Aryal S, Hiregange DG, Bashan A, Madmoni H, Olami M, Doniger T, Cohen-Chalamish S, Pescher P, Taoka M, Nobe Y, Fedorenko A, Bose T, Zimermann E, Prina E, Aharon-Hefetz N, Pilpel Y, Isobe T, Unger R, Späth GF, Yonath A, Michaeli S
Cell Rep 43 114203 (2024)
PMID: 38722744
Related structures: EMD-19576

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 89-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-244362 (preferred)
Entry contents:
76 distinct polypeptide molecules
13 distinct RNA molecules
Macromolecules (89 distinct):
Large ribosomal subunit protein uL2 C-terminal domain-containing protein Chain: LA
Molecule details ›
Chain: LA
Length: 260 amino acids
Theoretical weight: 28.33 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4FWX5 (Residues: 1-260; Coverage: 100%)
Gene names: LMJF_32_3900, LMJF_35_1430, LMJF_35_1440
Sequence domains:
Putative ribosomal protein L3 Chain: LB
Molecule details ›
Chain: LB
Length: 419 amino acids
Theoretical weight: 47.59 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q2Q6 (Residues: 1-419; Coverage: 100%)
Gene names: LMJF_32_3130, LMJF_34_2870, LMJF_34_2880, LMJF_34_2890, LMJF_34_2900
Sequence domains: Ribosomal protein L3
Large ribosomal subunit protein uL4 C-terminal domain-containing protein Chain: LC
Molecule details ›
Chain: LC
Length: 373 amino acids
Theoretical weight: 41.1 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9ADW5 (Residues: 1-373; Coverage: 100%)
Gene names: LMJF_29_1070, LMJF_29_1090
Sequence domains:
Large ribosomal subunit protein uL5 Chain: LD
Molecule details ›
Chain: LD
Length: 188 amino acids
Theoretical weight: 21.69 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: P48157 (Residues: 1-188; Coverage: 100%)
Gene names: LmjF22.0030, P1421.04, RPL11
Sequence domains:
Large ribosomal subunit protein uL6 alpha-beta domain-containing protein Chain: LE
Molecule details ›
Chain: LE
Length: 190 amino acids
Theoretical weight: 21.59 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QC91 (Residues: 1-190; Coverage: 100%)
Gene name: LMJF_21_1050
Sequence domains: Ribosomal protein L6
Putative 60S ribosomal protein L6 Chain: LF
Molecule details ›
Chain: LF
Length: 195 amino acids
Theoretical weight: 21.13 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q4D3 (Residues: 1-195; Coverage: 100%)
Gene name: LMJF_33_0720
Sequence domains: Ribosomal protein L6e
60S ribosomal protein L7a Chain: LG
Molecule details ›
Chain: LG
Length: 264 amino acids
Theoretical weight: 29.82 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QIP1 (Residues: 1-264; Coverage: 100%)
Gene names: LMJF_07_0500, LMJF_07_0510
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Putative 60S ribosomal protein L13a Chain: LH
Molecule details ›
Chain: LH
Length: 222 amino acids
Theoretical weight: 25.51 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QFG2 (Residues: 1-222; Coverage: 100%)
Gene name: LMJF_15_0200
Sequence domains: Ribosomal protein L13
Putative 60S ribosomal protein L13 Chain: LI
Molecule details ›
Chain: LI
Length: 220 amino acids
Theoretical weight: 24.85 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AEA8 (Residues: 1-220; Coverage: 100%)
Gene name: LMJF_29_2460
Sequence domains: Ribosomal protein L13e
Putative 60S ribosomal protein L23 Chain: LJ
Molecule details ›
Chain: LJ
Length: 139 amino acids
Theoretical weight: 14.98 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AFK3 (Residues: 1-139; Coverage: 100%)
Gene names: LMJF_35_3790, LMJF_35_3800
Sequence domains: Ribosomal protein L14p/L23e
Putative 40S ribosomal protein L14 Chain: LK
Molecule details ›
Chain: LK
Length: 175 amino acids
Theoretical weight: 19.95 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QBJ1 (Residues: 1-175; Coverage: 100%)
Gene names: LMJF_22_1520, LMJF_22_1560
Sequence domains:
Large ribosomal subunit protein uL15/eL18 domain-containing protein Chain: LL
Molecule details ›
Chain: LL
Length: 145 amino acids
Theoretical weight: 16.14 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AFK0 (Residues: 1-145; Coverage: 100%)
Gene names: LMJF_35_3760, LMJF_35_3780
Sequence domains: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
Ribosomal protein L15 Chain: LM
Molecule details ›
Chain: LM
Length: 204 amino acids
Theoretical weight: 24.5 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q6S3 (Residues: 1-204; Coverage: 100%)
Gene name: LMJF_30_3650
Sequence domains: Ribosomal L15
Putative 60S ribosomal protein L10 Chain: LN
Molecule details ›
Chain: LN
Length: 213 amino acids
Theoretical weight: 24.61 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: O97213 (Residues: 1-213; Coverage: 100%)
Gene names: LMJF_04_0750, LMJF_04_0950
Sequence domains: Ribosomal protein L16p/L10e
Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein Chain: LO
Molecule details ›
Chain: LO
Length: 305 amino acids
Theoretical weight: 34.06 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AF09 (Residues: 1-305; Coverage: 100%)
Gene names: LMJF_35_1880, LMJF_35_1900
Sequence domains:
Large ribosomal subunit protein eL18 Chain: LP
Molecule details ›
Chain: LP
Length: 198 amino acids
Theoretical weight: 22.07 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QG98 (Residues: 1-198; Coverage: 100%)
Gene names: LmjF13.0560, LmjF36.4510, LmjF_13_0560, LmjF_36_4510, RPL18-A, RPL18-B
Sequence domains: Ribosomal protein 60S L18 and 50S L18e
Large ribosomal subunit protein eL19 domain-containing protein Chain: LQ
Molecule details ›
Chain: LQ
Length: 254 amino acids
Theoretical weight: 28.9 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QJ37 (Residues: 1-254; Coverage: 100%)
Gene name: LMJF_06_0415
Sequence domains: Ribosomal protein L19e
60S ribosomal protein L18a Chain: LR
Molecule details ›
Chain: LR
Length: 179 amino acids
Theoretical weight: 20.85 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q5J4 (Residues: 1-179; Coverage: 100%)
Gene names: LMJF_32_0880, LMJF_35_0600
Sequence domains: Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
Putative 60S ribosomal protein L21 Chain: LS
Molecule details ›
Chain: LS
Length: 159 amino acids
Theoretical weight: 18.07 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QEX4 (Residues: 1-159; Coverage: 100%)
Gene name: LMJF_16_0460
Sequence domains: Ribosomal protein L21e
Putative 60S ribosomal protein L17 Chain: LT
Molecule details ›
Chain: LT
Length: 166 amino acids
Theoretical weight: 19.12 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QAX6 (Residues: 1-166; Coverage: 100%)
Gene name: LMJF_24_0040
Sequence domains: Ribosomal protein L22p/L17e
Large ribosomal subunit protein eL22 Chain: LU
Molecule details ›
Chain: LU
Length: 129 amino acids
Theoretical weight: 15.03 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q0X2 (Residues: 1-129; Coverage: 100%)
Gene names: LMJF_36_3270, LMJF_36_4420
Sequence domains: Ribosomal L22e protein family
Putative 60S ribosomal protein L23a Chain: LV
Molecule details ›
Chain: LV
Length: 145 amino acids
Theoretical weight: 16.37 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QJ20 (Residues: 1-145; Coverage: 100%)
Gene names: LMJF_06_0570, LMJF_06_0580
Sequence domains: Ribosomal protein L23
KOW domain-containing protein Chain: LW
Molecule details ›
Chain: LW
Length: 143 amino acids
Theoretical weight: 16.22 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QAC5 (Residues: 1-143; Coverage: 100%)
Gene names: LMJF_24_2050, LMJF_35_1670
Sequence domains:
Large ribosomal subunit protein eL24-related N-terminal domain-containing protein Chain: LX
Molecule details ›
Chain: LX
Length: 124 amino acids
Theoretical weight: 14.61 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q1W6 (Residues: 1-124; Coverage: 100%)
Gene names: LMJF_36_1070, LMJF_36_1100
Sequence domains: Ribosomal protein L24e
KOW domain-containing protein Chain: LY
Molecule details ›
Chain: LY
Length: 134 amino acids
Theoretical weight: 15.47 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q504 (Residues: 1-134; Coverage: 100%)
Gene names: LMJF_32_2690, LMJF_32_2710
Sequence domains:
Ribosomal eL28/Mak16 domain-containing protein Chain: LZ
Molecule details ›
Chain: LZ
Length: 147 amino acids
Theoretical weight: 16.31 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QGW7 (Residues: 1-147; Coverage: 100%)
Gene names: LMJF_11_1110, LMJF_11_1130
Sequence domains: Ribosomal L28e protein family
Putative 60S ribosomal protein L35 Chain: La
Molecule details ›
Chain: La
Length: 127 amino acids
Theoretical weight: 15.26 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q8V7 (Residues: 1-127; Coverage: 100%)
Gene names: LMJF_26_2330, LMJF_26_2340
Sequence domains: Ribosomal L29 protein
60S ribosomal protein L29 Chain: Lb
Molecule details ›
Chain: Lb
Length: 70 amino acids
Theoretical weight: 8 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q178 (Residues: 1-70; Coverage: 100%)
Gene names: LMJF_36_3390, LMJF_36_3400
Sequence domains: Ribosomal L29e protein family
Putative 60S ribosomal protein L7 Chain: Lc
Molecule details ›
Chain: Lc
Length: 252 amino acids
Theoretical weight: 28.9 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q9H4 (Residues: 1-252; Coverage: 100%)
Gene names: LMJF_26_0170, LMJF_26_0180
Sequence domains:
Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein Chain: Ld
Molecule details ›
Chain: Ld
Length: 104 amino acids
Theoretical weight: 11.37 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AEK1 (Residues: 1-104; Coverage: 100%)
Gene name: LMJF_35_0240
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Putative 60S ribosomal subunit protein L31 Chain: Le
Molecule details ›
Chain: Le
Length: 188 amino acids
Theoretical weight: 21.32 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AFF2 (Residues: 1-188; Coverage: 100%)
Gene names: LMJF_35_3280, LMJF_35_3290
Sequence domains: Ribosomal protein L31e
60S ribosomal protein L32 Chain: Lf
Molecule details ›
Chain: Lf
Length: 133 amino acids
Theoretical weight: 15.46 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QC11 (Residues: 1-133; Coverage: 100%)
Gene names: LMJF_21_1720, RPL32
Sequence domains: Ribosomal protein L32
Putative ribosomal protein l35a Chain: Lg
Molecule details ›
Chain: Lg
Length: 144 amino acids
Theoretical weight: 16.49 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QHL3 (Residues: 1-144; Coverage: 100%)
Gene names: LMJF_10_0070, LMJF_34_2470
Sequence domains: Ribosomal protein L35Ae
Putative 60S ribosomal protein L34 Chain: Lh
Molecule details ›
Chain: Lh
Length: 168 amino acids
Theoretical weight: 19.34 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QDP9 (Residues: 1-168; Coverage: 100%)
Gene name: LMJF_18_1400
Sequence domains: Ribosomal protein L34e
Putative 60S Ribosomal protein L36 Chain: Li
Molecule details ›
Chain: Li
Length: 105 amino acids
Theoretical weight: 11.98 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QCE1 (Residues: 1-105; Coverage: 100%)
Gene name: LMJF_21_0730
Sequence domains: Ribosomal protein L36e
Ribosomal protein L37 Chain: Lj
Molecule details ›
Chain: Lj
Length: 83 amino acids
Theoretical weight: 9.86 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AEH2 (Residues: 1-83; Coverage: 100%)
Gene name: LMJF_33_1955
Sequence domains: Ribosomal protein L37e
Putative ribosomal protein L38 Chain: Lk
Molecule details ›
Chain: Lk
Length: 83 amino acids
Theoretical weight: 9.48 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q8X0 (Residues: 1-83; Coverage: 100%)
Gene names: LMJF_03_0250, LMJF_26_2220
Sequence domains: Ribosomal L38e protein family
Putative 60S ribosomal protein L39 Chain: Ll
Molecule details ›
Chain: Ll
Length: 51 amino acids
Theoretical weight: 6.5 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QEQ0 (Residues: 1-51; Coverage: 100%)
Gene names: LMJF_16_1170, LMJF_29_2370
Sequence domains: Ribosomal L39 protein
Ubiquitin-ribosomal protein eL40 fusion protein Chain: Lm
Molecule details ›
Chain: Lm
Length: 128 amino acids
Theoretical weight: 14.71 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: P69201 (Residues: 1-128; Coverage: 100%)
Gene names: LmjF31.1900, LmjF31.2030, LmjF_31_1900, LmjF_31_2030, UB-EP52
Sequence domains:
60S ribosomal protein L41 Chain: Ln
Molecule details ›
Chain: Ln
Length: 34 amino acids
Theoretical weight: 4.39 KDa
Source organism: Leishmania major strain Friedlin
Putative 60S ribosomal protein L37a Chain: Lo
Molecule details ›
Chain: Lo
Length: 92 amino acids
Theoretical weight: 10.34 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QC01 (Residues: 1-92; Coverage: 100%)
Gene names: LMJF_21_1820, LMJF_36_1925
Sequence domains: Ribosomal L37ae protein family
Putative 60S ribosomal protein L44 Chain: Lp
Molecule details ›
Chain: Lp
Length: 106 amino acids
Theoretical weight: 12.3 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q3L3 (Residues: 1-106; Coverage: 100%)
Gene names: LMJF_13_1670, LMJF_33_3230
Sequence domains: Ribosomal protein L44
Small ribosomal subunit protein eS1 Chain: SA
Molecule details ›
Chain: SA
Length: 264 amino acids
Theoretical weight: 30.06 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4FX73 (Residues: 1-264; Coverage: 100%)
Gene names: LmjF.35.0400, LmjF.35.0410, LmjF.35.0420
Sequence domains: Ribosomal S3Ae family
Small ribosomal subunit protein uS2 Chain: SB
Molecule details ›
Chain: SB
Length: 246 amino acids
Theoretical weight: 27.54 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q0Q0 (Residues: 1-246; Coverage: 100%)
Gene names: LmjF36.5010, LmjF36.5120, LmjF_36_5010, LmjF_36_5120
Sequence domains: Ribosomal protein S2
40S ribosomal protein S3 Chain: SC
Molecule details ›
Chain: SC
Length: 219 amino acids
Theoretical weight: 24.51 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q4A0 (Residues: 1-219; Coverage: 100%)
Gene names: LMJF_15_0950, LMJF_33_0920
Sequence domains:
Putative 40S ribosomal protein S9 Chain: SD
Molecule details ›
Chain: SD
Length: 190 amino acids
Theoretical weight: 22.19 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QIM3 (Residues: 1-190; Coverage: 100%)
Gene name: LMJF_07_0680
Sequence domains:
40S ribosomal protein S4 Chain: SE
Molecule details ›
Chain: SE
Length: 273 amino acids
Theoretical weight: 30.74 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QG31 (Residues: 1-273; Coverage: 100%)
Gene names: LMJF_13_1220, LMJF_13_1230, RS4
Sequence domains:
Small ribosomal subunit protein uS5 Chain: SF
Molecule details ›
Chain: SF
Length: 265 amino acids
Theoretical weight: 28.79 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QDL5 (Residues: 1-265; Coverage: 100%)
Gene name: LMJF_19_0060
Sequence domains:
Small ribosomal subunit protein eS6 Chain: SG
Molecule details ›
Chain: SG
Length: 249 amino acids
Theoretical weight: 28.37 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q9NE83 (Residues: 1-249; Coverage: 100%)
Gene names: L3640.11, LmjF21.1780, LmjF_21_1780, Lmj_1130, RPS6
Sequence domains: Ribosomal protein S6e
Small ribosomal subunit protein uS7 domain-containing protein Chain: SH
Molecule details ›
Chain: SH
Length: 190 amino acids
Theoretical weight: 21.34 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q868B1 (Residues: 1-190; Coverage: 100%)
Gene names: LMJF_11_0960, LMJF_11_0970
Sequence domains: Ribosomal protein S7p/S5e
40S ribosomal protein S7 Chain: SI
Molecule details ›
Chain: SI
Length: 200 amino acids
Theoretical weight: 23.77 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AC32 (Residues: 1-200; Coverage: 100%)
Gene names: LMJF_01_0410, LMJF_01_0420
Sequence domains: Ribosomal protein S7e
Putative 40S ribosomal protein S15A Chain: SJ
Molecule details ›
Chain: SJ
Length: 130 amino acids
Theoretical weight: 14.72 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QGW3 (Residues: 1-130; Coverage: 100%)
Gene names: LMJF_11_1190, LMJF_29_1800
Sequence domains: Ribosomal protein S8
Small ribosomal subunit protein eS8 Chain: SK
Molecule details ›
Chain: SK
Length: 220 amino acids
Theoretical weight: 24.98 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: P25204 (Residues: 1-220; Coverage: 100%)
Gene names: LmjF24.2070, LmjF24.2080, LmjF_24_2070, LmjF_24_2080, RPS8, RPS8A, RPS8B
Sequence domains: Ribosomal protein S8e
Ribosomal protein S16 Chain: SL
Molecule details ›
Chain: SL
Length: 149 amino acids
Theoretical weight: 16.72 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q9A5 (Residues: 1-149; Coverage: 100%)
Gene names: LMJF_26_0880, LMJF_26_0890
Sequence domains: Ribosomal protein S9/S16
Small ribosomal subunit protein uS10 domain-containing protein Chain: SM
Molecule details ›
Chain: SM
Length: 116 amino acids
Theoretical weight: 13.03 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q8G4 (Residues: 1-116; Coverage: 100%)
Gene names: LMJF_28_1010, LMJF_28_1030
Sequence domains: Ribosomal protein S10p/S20e
Plectin/eS10 N-terminal domain-containing protein Chain: SN
Molecule details ›
Chain: SN
Length: 168 amino acids
Theoretical weight: 18.68 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q1X7 (Residues: 1-168; Coverage: 100%)
Gene names: LMJF_36_0980, LMJF_36_0990
Sequence domains: Plectin/S10 domain
40S ribosomal protein S14 Chain: SO
Molecule details ›
Chain: SO
Length: 144 amino acids
Theoretical weight: 15.62 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q8H1 (Residues: 1-144; Coverage: 100%)
Gene name: LMJF_28_0960
Sequence domains: Ribosomal protein S11
Putative 40S ribosomal protein S23 Chain: SP
Molecule details ›
Chain: SP
Length: 143 amino acids
Theoretical weight: 15.97 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QC89 (Residues: 1-143; Coverage: 100%)
Gene names: LMJF_21_1060, LMJF_21_1070
Sequence domains: Ribosomal protein S12/S23
40S ribosomal protein S12 Chain: SQ
Molecule details ›
Chain: SQ
Length: 141 amino acids
Theoretical weight: 15.63 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QG97 (Residues: 1-141; Coverage: 100%)
Gene name: LMJF_13_0570
Sequence domains: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Ribosomal protein S18 Chain: SR
Molecule details ›
Chain: SR
Length: 153 amino acids
Theoretical weight: 17.43 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q1Y3 (Residues: 66-218; Coverage: 70%)
Gene name: LMJF_36_0930
Sequence domains: Ribosomal protein S13/S18
Putative ribosomal protein S29 Chain: SS
Molecule details ›
Chain: SS
Length: 57 amino acids
Theoretical weight: 6.7 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q817 (Residues: 1-57; Coverage: 100%)
Gene names: LMJF_28_2205, LMJF_28_2460
Sequence domains: Ribosomal protein S14p/S29e
Small ribosomal subunit protein uS15 N-terminal domain-containing protein Chain: ST
Molecule details ›
Chain: ST
Length: 151 amino acids
Theoretical weight: 17.48 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q3M1 (Residues: 1-151; Coverage: 100%)
Gene names: LMJF_19_0390, LMJF_33_3150
Sequence domains:
Ribosomal protein S17 family protein Chain: SU
Molecule details ›
Chain: SU
Length: 173 amino acids
Theoretical weight: 20.02 KDa
Source organism: Leishmania major strain Friedlin
Putative 40S ribosomal protein S17 Chain: SV
Molecule details ›
Chain: SV
Length: 143 amino acids
Theoretical weight: 16.55 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q806 (Residues: 1-143; Coverage: 100%)
Gene names: LMJF_28_2555, LMJF_28_2560
Sequence domains: Ribosomal S17
Putative 40S ribosomal protein S15 Chain: SW
Molecule details ›
Chain: SW
Length: 152 amino acids
Theoretical weight: 17.47 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QBV0 (Residues: 1-152; Coverage: 100%)
Gene names: LMJF_22_0420, LMJF_22_0460
Sequence domains: Ribosomal protein S19
40S ribosomal protein S19-like protein Chain: SX
Molecule details ›
Chain: SX
Length: 161 amino acids
Theoretical weight: 18.16 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: E9AEE8 (Residues: 1-161; Coverage: 100%)
Gene name: LMJF_29_2860
Sequence domains: Ribosomal protein S19e
Putative 40S ribosomal protein S21 Chain: SY
Molecule details ›
Chain: SY
Length: 164 amino acids
Theoretical weight: 17.04 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QH01 (Residues: 1-164; Coverage: 100%)
Gene names: LMJF_11_0760, LMJF_11_0780
Sequence domains: Ribosomal protein S21e
40S ribosomal protein S24 Chain: SZ
Molecule details ›
Chain: SZ
Length: 137 amino acids
Theoretical weight: 15.81 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q1D2 (Residues: 1-137; Coverage: 100%)
Gene names: LMJF_36_2860, LMJF_36_2870, S24E-1, S24E-2
Sequence domains: Ribosomal protein S24e
40S ribosomal protein S25 Chain: Sa
Molecule details ›
Chain: Sa
Length: 120 amino acids
Theoretical weight: 13.07 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q9X4 (Residues: 1-120; Coverage: 100%)
Gene name: LMJF_25_1190
Sequence domains: S25 ribosomal protein
40S ribosomal protein S26 Chain: Sb
Molecule details ›
Chain: Sb
Length: 112 amino acids
Theoretical weight: 12.79 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q8L6 (Residues: 1-112; Coverage: 100%)
Gene name: LMJF_28_0540
Sequence domains: Ribosomal protein S26e
40S ribosomal protein S27-1 Chain: Sc
Molecule details ›
Chain: Sc
Length: 86 amino acids
Theoretical weight: 9.82 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q140 (Residues: 1-86; Coverage: 100%)
Gene name: LMJF_36_3750
Sequence domains: Ribosomal protein S27
Putative 40S ribosomal protein S33 Chain: Sd
Molecule details ›
Chain: Sd
Length: 87 amino acids
Theoretical weight: 9.76 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q931 (Residues: 1-87; Coverage: 100%)
Gene names: LMJF_26_1630, LMJF_26_1640, S33-1, S33-2
Sequence domains: Ribosomal protein S28e
40S ribosomal protein S30 Chain: Se
Molecule details ›
Chain: Se
Length: 66 amino acids
Theoretical weight: 7.39 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q7P0 (Residues: 1-66; Coverage: 100%)
Gene names: LMJF_30_0670, LMJF_30_0680, LMJF_30_0690
Sequence domains: Ribosomal protein S30
Ubiquitin-ribosomal protein eL40 fusion protein Chain: Sf
Molecule details ›
Chain: Sf
Length: 152 amino acids
Theoretical weight: 17.06 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4QFK7 (Residues: 1-152; Coverage: 100%)
Gene name: LMJF_14_1270
Sequence domains:
Activated protein kinase c receptor (LACK) Chain: Sg
Molecule details ›
Chain: Sg
Length: 312 amino acids
Theoretical weight: 34.44 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q7Y7 (Residues: 1-312; Coverage: 100%)
Gene names: LACK1, LACK2, LMJF_28_2740, LMJF_28_2750
Sequence domains: WD domain, G-beta repeat
RRM domain-containing protein Chain: Sh
Molecule details ›
Chain: Sh
Length: 235 amino acids
Theoretical weight: 25.23 KDa
Source organism: Leishmania major strain Friedlin
UniProt:
  • Canonical: Q4Q5K7 (Residues: 1-235; Coverage: 100%)
Gene name: LMJF_32_0750
Sequence domains: RNA recognition motif
LSUa_rRNA_chain_1 Chain: L1
Molecule details ›
Chain: L1
Length: 1782 nucleotides
Theoretical weight: 577.07 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
LSUb_rRNA_chain_2 Chain: L2
Molecule details ›
Chain: L2
Length: 1526 nucleotides
Theoretical weight: 492.59 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
SR1_chain_3 Chain: L3
Molecule details ›
Chain: L3
Length: 216 nucleotides
Theoretical weight: 69.15 KDa
SR2_chain_4 Chain: L4
Molecule details ›
Chain: L4
Length: 184 nucleotides
Theoretical weight: 59.47 KDa
Sequence domains: Eukaryotic large subunit ribosomal RNA
SR4_chain_5 Chain: L5
Molecule details ›
Chain: L5
Length: 135 nucleotides
Theoretical weight: 43.5 KDa
SR6_chain_6 Chain: L6
Molecule details ›
Chain: L6
Length: 73 nucleotides
Theoretical weight: 23.34 KDa
5.8S_rRNA_chain_7 Chain: L7
Molecule details ›
Chain: L7
Length: 171 nucleotides
Theoretical weight: 54.98 KDa
Sequence domains: 5.8S ribosomal RNA
5S_rRNA_chain_8 Chain: L8
Molecule details ›
Chain: L8
Length: 124 nucleotides
Theoretical weight: 39.76 KDa
Sequence domains: 5S ribosomal RNA
SSU_rRNA_chain_S1 Chain: S1
Molecule details ›
Chain: S1
Length: 2204 nucleotides
Theoretical weight: 710.67 KDa
Sequence domains: Eukaryotic small subunit ribosomal RNA
A-site_tRNA_chain_S2 Chain: S2
Molecule details ›
Chain: S2
Length: 76 nucleotides
Theoretical weight: 24.6 KDa
Sequence domains: tRNA
P-site_tRNA_chain_S3 Chain: S3
Molecule details ›
Chain: S3
Length: 77 nucleotides
Theoretical weight: 24.79 KDa
Sequence domains: tRNA
E-site_tRNA_chain_S4 Chain: S4
Molecule details ›
Chain: S4
Length: 76 nucleotides
Theoretical weight: 24.49 KDa
Sequence domains: tRNA
mRNA_chain_S5 Chain: S5
Molecule details ›
Chain: S5
Length: 13 nucleotides
Theoretical weight: 4.09 KDa

Ligands and Environments

5 bound ligands:
Ligand MG 289 x MG
Ligand NA 86 x NA
Ligand K 143 x K
Ligand A1H4F 1 x A1H4F
Ligand ZN 1 x ZN
9 modified residues:
Ligand OMU 21 x OMU
Ligand A2M 36 x A2M
Ligand PSU 61 x PSU
Ligand OMC 16 x OMC
Ligand OMG 27 x OMG
Ligand 5MC 4 x 5MC
Ligand 7MG 1 x 7MG
Ligand MA6 2 x MA6
Ligand MIA 1 x MIA

Experiments and Validation Details

Entry percentile scores
Resolution: 2.93Å
Relevant EMDB volumes: EMD-19576

Quick links

Citations

1 review citation

Ribosome Structural Changes Dynamically Affect Ribosome Function.
Lindahl L. (2024)