› 8s1m

X-ray diffraction
2.05Å resolution

Crystal structure of human GABARAP fused to EGFR (1076-1099)

Released:
DOI: 10.2210/pdb8s1m/pdb
PDB entry 8s1m coloured by chain, front view.
PDB entry 8s1m coloured by chain, side view.
PDB entry 8s1m coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ueffing A, Willbold D, Weiergraeber OH

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271912 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor; Gamma-aminobutyric acid receptor-associated protein Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00533 (Residues: 1076-1099; Coverage: 2%)
  • Canonical: O95166 (Residues: 1-117; Coverage: 100%)
Gene names: EGFR, ERBB, ERBB1, FLC3B, GABARAP, HER1, HT004
Sequence domains: Autophagy protein Atg8 ubiquitin like

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: I23
Unit cell:
a: 101.28Å b: 101.28Å c: 101.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.23
Expression system: Escherichia coli BL21(DE3)

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