› 8s4f

X-ray diffraction
1.39Å resolution

Function and Biology Details

Reactions catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Urea = cyanamide + H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 28.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00915 (Residues: 3-261; Coverage: 99%)
Gene name: CA1
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

7 bound ligands:
Ligand ZN 2 x ZN
Ligand PPI 1 x PPI
Ligand TRS 1 x TRS
Ligand DMS 1 x DMS
Ligand EDO 5 x EDO
Ligand VV8 2 x VV8
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: P212121
Unit cell:
a: 62.415Å b: 73.265Å c: 120.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.234
Expression system: Escherichia coli BL21(DE3)

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