› 8s4y

X-ray diffraction
2.7Å resolution

Crystal structure of an APP-talin (F2F3) chimera

Released:
DOI: 10.2210/pdb8s4y/pdb
PDB entry 8s4y coloured by chain, front view.
PDB entry 8s4y coloured by chain, side view.
PDB entry 8s4y coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Ball NJ, Ellis C, Goult BT

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-276145 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C31 Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.99 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P12023 (Residues: 754-764; Coverage: 2%)
Gene names: A4, AD1, App
Talin-1 Chain: B
Molecule details ›
Chain: B
Length: 192 amino acids
Theoretical weight: 22.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P54939 (Residues: 209-400; Coverage: 8%)
Gene names: TLN, TLN1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 60.388Å b: 64.081Å c: 65.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.211 0.267
Expression system: Escherichia coli

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