8s5i

Electron Microscopy
3.1Å resolution

Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, single particle reconstruction

Released:

Function and Biology Details

Reaction catalysed:
L-serine + L-homocysteine = L-cystathionine + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
PDBe Complex ID:
PDB-CPX-273622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystathionine beta-synthase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 559 amino acids
Theoretical weight: 61.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35520 (Residues: 1-551; Coverage: 100%)
Gene name: CBS
Sequence domains:

Ligands and Environments


Cofactor: Ligand HEM 6 x HEM
No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-19736
Expression system: Escherichia coli