› 8s6b

Electron Microscopy
2.06Å resolution

CryoEM structure of Apo form of catalytic domain of human HMG-CoA reductase

Released:
DOI: 10.2210/pdb8s6b/pdb
PDB entry 8s6b coloured by chain, front view.
PDB entry 8s6b coloured by chain, side view.
PDB entry 8s6b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Karuppasamy M, van Rooyen J
Acta Crystallogr F Struct Biol Commun (2025)
PMID: 39976191
Related structures: EMD-19757

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-287876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxy-3-methylglutaryl-coenzyme A reductase Chain: A
Molecule details ›
Chain: A
Length: 423 amino acids
Theoretical weight: 45.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.06Å
Relevant EMDB volumes: EMD-19757
Expression system: Escherichia coli

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