› 8s7c

X-ray diffraction
4.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-243412 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
VWFA and cache domain-containing protein 1 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 1102 amino acids
Theoretical weight: 123.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PDJ1 (Residues: 1-1094; Coverage: 84%)
Gene names: Cachd1, Kiaa1573, Vwcd1
Frizzled-5 Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 140 amino acids
Theoretical weight: 15.92 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9EQD0 (Residues: 27-156; Coverage: 23%)
Gene name: Fzd5
Sequence domains: Fz domain
Low-density lipoprotein receptor-related protein 6 Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 628 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75581 (Residues: 629-1244; Coverage: 39%)
Gene name: LRP6
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 30 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 283.697Å b: 198.236Å c: 218.824Å
α: 90° β: 128.07° γ: 90°
R-values:
R R work R free
0.209 0.206 0.261
Expression system: Homo sapiens

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