› 8s92

Electron Microscopy
4.06Å resolution

Structure of N-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP

Released:
DOI: 10.2210/pdb8s92/pdb
PDB entry 8s92 coloured by chain, front view.
PDB entry 8s92 coloured by chain, side view.
PDB entry 8s92 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activity, substrate preference and structure of the HsMCM8/9 helicase.
McKinzey DR, Li C, Gao Y, Trakselis MA
OpenAccess logo Nucleic Acids Res (2023)
PMID: 37309874
Related structures: EMD-40235

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192684 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA helicase MCM8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 840 amino acids
Theoretical weight: 93.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9UJA3 (Residues: 1-840; Coverage: 100%)
Gene names: C20orf154, MCM8
Sequence domains:
DNA helicase MCM9 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 1143 amino acids
Theoretical weight: 127.49 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NXL9 (Residues: 1-1143; Coverage: 100%)
Gene names: C6orf61, MCM9, MCMDC1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.06Å
Relevant EMDB volumes: EMD-40235
Expression system: Trichoplusia ni

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