› 8sdg

X-ray diffraction
2.71Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-276099 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neutralizing antibody CC25.43 heavy chain Chains: A, G
Molecule details ›
Chains: A, G
Length: 226 amino acids
Theoretical weight: 24.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Neutralizing antibody CC25.43 light chain Chains: B, I
Molecule details ›
Chains: B, I
Length: 215 amino acids
Theoretical weight: 23.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 205 amino acids
Theoretical weight: 23.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0DTC2 (Residues: 333-530; Coverage: 16%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 311.948Å b: 83.786Å c: 74.15Å
α: 90° β: 100.8° γ: 90°
R-values:
R R work R free
0.257 0.255 0.308
Expression systems:
  • Homo sapiens
  • Trichoplusia ni

Quick links

Citations

1 review citation

The D Gene in CDR H3 Determines a Public Class of Human Antibodies to SARS-CoV-2.
Yuan et al. (2024)

1 mention without citation

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Song et al. (2023)