› 8sdy

Electron Microscopy
2.79Å resolution

Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH)

Released:
DOI: 10.2210/pdb8sdy/pdb
PDB entry 8sdy coloured by chain, front view.
PDB entry 8sdy coloured by chain, side view.
PDB entry 8sdy coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Dou T, Lian T, Shu S, He Y, Jiang J
Nat Struct Mol Biol (2023)
PMID: 37845412
Related structures: EMD-40354

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-221647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 22 member 6 Chain: A
Molecule details ›
Chain: A
Length: 551 amino acids
Theoretical weight: 60.82 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35956 (Residues: 1-551; Coverage: 100%)
Gene names: Oat1, Slc22a6
Sequence domains: Sugar (and other) transporter

Ligands and Environments

1 bound ligand:
Ligand ZWD 1 x ZWD
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.79Å
Relevant EMDB volumes: EMD-40354
Expression system: Homo sapiens

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