› 8sel

Electron Microscopy
3.8Å resolution

Type IIIb beta-amyloid 40 Filaments from Down Syndrome

Released:
DOI: 10.2210/pdb8sel/pdb
PDB entry 8sel coloured by chain, front view.
PDB entry 8sel coloured by chain, side view.
PDB entry 8sel coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome.
Fernandez A, Hoq MR, Hallinan GI, Li D, Bharath SR, Vago FS, Zhang X, Ozcan KA, Newell KL, Garringer HJ, Jiang W, Ghetti B, Vidal R
Nat Struct Mol Biol (2024)
PMID: 38553642
Related structures: EMD-40421

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 40 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 40 amino acids
Theoretical weight: 4.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-711; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-40421

Quick links

Citations

1 citations in other articles

Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Ghosh et al. (2024)