› 8sf0

Electron Microscopy
2.9Å resolution

Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD)

Released:
DOI: 10.2210/pdb8sf0/pdb
PDB entry 8sf0 coloured by chain, front view.
PDB entry 8sf0 coloured by chain, side view.
PDB entry 8sf0 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Cholak S, Saville JW, Zhu X, Berezuk AM, Tuttle KS, Haji-Ghassemi O, Alvarado FJ, Van Petegem F, Subramaniam S
Structure (2023)
PMID: 37192614
Related structures: EMD-40435

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 565.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-5037; Coverage: 100%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CMP 4 x CMP
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-40435

Quick links

Citations

3 citation in other articles

Dopamine, norepinephrine, and vasopressin accelerate particle transport velocity in murine tracheal epithelium via substance-specific receptor pathways: dependency on intra- and extracellular Ca2+ sources.
Schmidt et al. (2024)
2 more