› 8sge

X-ray diffraction
1.51Å resolution

KLHDC2 Kelch Domain with ligand KDRLKZ-1

Released:
DOI: 10.2210/pdb8sge/pdb
PDB entry 8sge coloured by chain, front view.
PDB entry 8sge coloured by chain, side view.
PDB entry 8sge coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Hickey CM, Digianantonio KM, Zimmermann K, Harbin A, Quinn C, Patel A, Gareiss P, Chapman A, Tiberi B, Dobrodziej J, Corradi J, Cacace AM, Langley DR, Békés M
Nat Struct Mol Biol (2024)
PMID: 38177675

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-221498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch domain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 362 amino acids
Theoretical weight: 41.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y2U9 (Residues: 2-362; Coverage: 89%)
Gene names: HCA33, KLHDC2
Sequence domains: Galactose oxidase, central domain

Ligands and Environments

2 bound ligands:
Ligand GOL 9 x GOL
Ligand ZWS 2 x ZWS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 44.9Å b: 88.49Å c: 89.22Å
α: 90° β: 104.45° γ: 90°
R-values:
R R work R free
0.18 0.179 0.206
Expression system: Spodoptera frugiperda

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