› 8sgh

Electron Microscopy
3.17Å resolution

Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS

Released:
DOI: 10.2210/pdb8sgh/pdb
PDB entry 8sgh coloured by chain, front view.
PDB entry 8sgh coloured by chain, side view.
PDB entry 8sgh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders.
Gonzalez A, Kim HJ, Freibaum BD, Fung HYJ, Brautigam CA, Taylor JP, Chook YM
Structure (2023)
PMID: 37279758
Related structures: EMD-40455

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273915 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 894 amino acids
Theoretical weight: 101.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 8-898; Coverage: 99%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed Chain: B
Molecule details ›
Chain: B
Length: 126 amino acids
Theoretical weight: 13.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55795 (Residues: 103-225; Coverage: 27%)
Gene names: FTP3, HNRNPH2, HNRPH2
Sequence domains: RNA recognition motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.17Å
Relevant EMDB volumes: EMD-40455
Expression system: Escherichia coli BL21(DE3)

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