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human liver mitochondrial Short-chain specific acyl-CoA dehydrogenase

Electron Microscopy
3.15Å resolution
PDB entry 8sgs coloured by chain, front view.
PDB entry 8sgs coloured by chain, side view.
PDB entry 8sgs coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
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Multimeric state: homo tetramer
Accessible surface area: 48411.7 Å2
Buried surface area: 25953.41 Å2
Dissociation area: 4,187.12 Å2
Dissociation energy (ΔGdiss): 71.62 kcal/mol
Dissociation entropy (TΔSdiss): 16.02 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-147660

Macromolecules

Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 412 amino acids
Theoretical weight: 44.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16219 (Residues: 1-412; Coverage: 100%)
Gene name: ACADS
Pfam:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 8sgs, assembly 1, front view.
Short-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 8sgs, assembly 1, side view.
Short-chain specific acyl-CoA dehydrogenase, mitochondrial in PDB entry 8sgs, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P16219  
141250100150200250300350400
 
100200300400MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
UniProt
P16219
Chains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
Variants
Molecule details ›

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