› 8si8

Electron Microscopy
2.99Å resolution

Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in closed state

Released:
DOI: 10.2210/pdb8si8/pdb
PDB entry 8si8 coloured by chain, front view.
PDB entry 8si8 coloured by chain, side view.
PDB entry 8si8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mechanisms of TRPM7 activation and inhibition.
Nadezhdin KD, Correia L, Narangoda C, Patel DS, Neuberger A, Gudermann T, Kurnikova MG, Chubanov V, Sobolevsky AI
OpenAccess logo Nat Commun 14 2639 (2023)
PMID: 37156763
Related structures: EMD-40502

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TRPM7 channel, cleaved form Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1279 amino acids
Theoretical weight: 146.9 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q923J1 (Residues: 2-1280; Coverage: 69%)
Gene names: Chak, Ltrpc7, Trpm7
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand POV 52 x POV
Ligand 3FD 4 x 3FD
Ligand CLR 4 x CLR
Ligand DU0 4 x DU0
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.99Å
Relevant EMDB volumes: EMD-40502
Expression system: Homo sapiens

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Citations

2 review citations

Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 3: the roles and properties of TRPM2 and TRPM7.
Okada et al. (2023)
1 more