› 8sic

X-ray diffraction
2.76Å resolution

Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine

Released:
DOI: 10.2210/pdb8sic/pdb
PDB entry 8sic coloured by chain, front view.
PDB entry 8sic coloured by chain, side view.
PDB entry 8sic coloured by chain, top view.
Source organisms:
Entry authors: Joyce MG, Jensen JL, Chen WH, Kanekiyo M

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243125 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cy137C02 Fab heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 222 amino acids
Theoretical weight: 23.81 KDa
Source organism: Macaca fascicularis
Expression system: Homo sapiens
Cy137C02 Fab light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 215 amino acids
Theoretical weight: 22.81 KDa
Source organism: Macaca fascicularis
Expression system: Homo sapiens
Envelope glycoprotein GP350 Chains: E, G
Molecule details ›
Chains: E, G
Length: 431 amino acids
Theoretical weight: 46.9 KDa
Source organism: Human herpesvirus 4 strain B95-8
Expression system: Homo sapiens
UniProt:
  • Canonical: P03200 (Residues: 1-425; Coverage: 47%)
Gene name: BLLF1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 17 x NAG
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Unit cell:
a: 69.047Å b: 71.377Å c: 395.083Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.246 0.295
Expression system: Homo sapiens

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