› 8skv

Electron Microscopy
3.1Å resolution

Structure of human SIgA1 in complex with Streptococcus pyogenes protein M4 (Arp4)

Released:
DOI: 10.2210/pdb8skv/pdb
PDB entry 8skv coloured by chain, front view.
PDB entry 8skv coloured by chain, side view.
PDB entry 8skv coloured by chain, top view.
Source organisms:
Primary publication:
SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Liu Q, Stadtmueller BM
OpenAccess logo Nat Commun 14 6726 (2023)
PMID: 37872175
Related structures: EMD-40568

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-232735 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Immunoglobulin heavy constant alpha 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 353 amino acids
Theoretical weight: 37.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01876 (Residues: 1-333; Coverage: 84%)
  • Best match: P01876-1 (Residues: 1-353)
Gene name: IGHA1
Sequence domains:
Secretory component Chain: E
Molecule details ›
Chain: E
Length: 553 amino acids
Theoretical weight: 61.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01833 (Residues: 19-565; Coverage: 73%)
Gene name: PIGR
Sequence domains: Immunoglobulin V-set domain
Immunoglobulin J chain Chain: J
Molecule details ›
Chain: J
Length: 137 amino acids
Theoretical weight: 15.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01591 (Residues: 23-159; Coverage: 100%)
Gene names: IGCJ, IGJ, JCHAIN
Sequence domains: Immunoglobulin J chain
IgA receptor Chains: a, b
Molecule details ›
Chains: a, b
Length: 321 amino acids
Theoretical weight: 37.35 KDa
Source organism: Streptococcus pyogenes serotype M4
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P13050 (Residues: 42-356; Coverage: 91%)
Gene name: arp4
Sequence domains: M protein repeat

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 7 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-40568
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21

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