› 8slp

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-2

Released:
DOI: 10.2210/pdb8slp/pdb
PDB entry 8slp coloured by chain, front view.
PDB entry 8slp coloured by chain, side view.
PDB entry 8slp coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel.
Karuppan S, Schrag LG, Pastrano CM, Jara-Oseguera A, Zubcevic L
Proc Natl Acad Sci U S A 121 e2403333121 (2024)
PMID: 38923985
Related structures: EMD-40579

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-247316 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel, subfamily M, member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1169 amino acids
Theoretical weight: 132.35 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: F1LMD7 (Residues: 32-186, 187-1187; Coverage: 97%)
Gene name: Trpm5
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-40579
Expression system: Homo sapiens

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