› 8sly

Electron Microscopy
3.32Å resolution

Rat TRPV2 bound with 2 CBD ligands in nanodiscs

Released:
DOI: 10.2210/pdb8sly/pdb
PDB entry 8sly coloured by chain, front view.
PDB entry 8sly coloured by chain, side view.
PDB entry 8sly coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Gochman A, Tan XF, Bae C, Chen H, Swartz KJ, Jara-Oseguera A
Elife 12 (2023)
PMID: 37199723
Related structures: EMD-40583

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 761 amino acids
Theoretical weight: 86.8 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9WUD2 (Residues: 1-761; Coverage: 100%)
Gene names: Sac2b, Trpv2, Vrl1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand P0T 8 x P0T
Ligand NA 1 x NA
Ligand POV 4 x POV
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.32Å
Relevant EMDB volumes: EMD-40583
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Dilation of ion selectivity filters in cation channels.
Huffer et al. (2024)
1 more

2 mentions without citation

Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Gochman et al. (2023)
1 more