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Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state

Source organisms:
Biochemical function: hyaluronan synthase activity
Biological process: extracellular matrix assembly
Cellular component: membrane

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EC 2.4.1.212: Hyaluronan synthase

Reaction catalysed:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
Systematic name:
Alternating UDP-N-acetyl-alpha-D-glucosamine:beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) 3-beta-D-glucuronosyltransferase (configuration-inverting)
Alternative Name(s):
  • Alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) 3-beta-D-glucuronosyltransferase
  • HAS
  • SeHAS
  • SpHAS

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13641
Domain description: Glycosyltransferase like family 2
Occurring in:
  1. Hyaluronan synthase 1

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