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Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2

Electron Microscopy
2.78Å resolution
PDB entry 8sno coloured by chain, front view.
PDB entry 8sno coloured by chain, side view.
PDB entry 8sno coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Disintegrin and metalloproteinase domain-containing protein 17 and Inactive rhomboid protein 2
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Multimeric state: hetero dimer
Accessible surface area: 36204.88 Å2
Buried surface area: 4004.31 Å2
Dissociation area: 2,002.16 Å2
Dissociation energy (ΔGdiss): 15.2 kcal/mol
Dissociation entropy (TΔSdiss): 14.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-282875

Macromolecules

Disintegrin and metalloproteinase domain-containing protein 17
Chain: A
Length: 610 amino acids
Theoretical weight: 68.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78536 (Residues: 215-824; Coverage: 76%)
Gene names: ADAM17, CSVP, TACE
Pfam:
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 8sno, assembly 1, front view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 8sno, assembly 1, side view.
Disintegrin and metalloproteinase domain-containing protein 17 in PDB entry 8sno, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P78536  
161050100150200250300350400450500550600
 
200400600RADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
UniProt
P78536
Chains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Inactive rhomboid protein 2
Chain: B
Length: 827 amino acids
Theoretical weight: 93.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PJF5 (Residues: 1-856; Coverage: 97%)
  • Best match: Q6PJF5-2 (Residues: 1-827)
Gene names: IRHOM2, RHBDF2, RHBDL5, RHBDL6
Pfam:
Inactive rhomboid protein 2 in PDB entry 8sno, assembly 1, front view.
Inactive rhomboid protein 2 in PDB entry 8sno, assembly 1, side view.
Inactive rhomboid protein 2 in PDB entry 8sno, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q6PJF5  
1827100200300400500600700800
 
200400600800MASADKNGGSVSSVSSSRLQSRKPPNLSITIPPPEKETQAPGEQDSMLPERKNPAYLKSVSLQEPRSRWQESSEKRPGFRRQASLSQSIRKGAAQWFGVSGDWEGQRQQWQRRSLHHCSMRYGRLKASCQRDLELPSQEAPSFQGTESPKPCKMPKIVDPLARGRAFRHPEEMDRPHAPHPPLTPGVLSLTSFTSVRSGYSHLPRRKRMSVAHMSLQAAAALLKGRSVLDATGQRCRVVKRSFAFPSFLEEDVVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGIPHSASPVSPDGVQIPLKEYGRAPVPGPRRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHVIITLLVICTYGIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWVGPSSIDLIHLGAKFSPCIRKDGQIEQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKRTSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCEIKGRPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWPLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLAFAGLFAALVLWLYIYPINWPWIEHLTCFPFTSRFCEKYELDQVLH
UniProt
Q6PJF5
Chains
Secondary structure
Flexibility predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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