Function and Biology

OXA-48 bound to inhibitor CDD-2725

Source organism: Klebsiella pneumoniae
Biochemical function: beta-lactamase activity
Biological process: antibiotic catabolic process
Cellular component: not assigned

EC 3.5.2.6: Beta-lactamase

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Systematic name:
Beta-lactam hydrolase
Alternative Name(s):
  • Ampicillinase
  • Beta-lactamase A, B, C
  • Beta-lactamase AME I
  • Beta-lactamase I-III
  • Cephalosporin-beta-lactamase
  • Cephalosporinase
  • Exopenicillinase
  • Neutrapen
  • Penicillin amido-beta-lactamhydrolase
  • Penicillin beta-lactamase
  • Penicillinase
  • Penicillinase I, II

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. Beta-lactamase OXA-48
The deposited structure of PDB entry 8sqf contains 2 copies of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in Beta-lactamase. Showing 1 copy in chain A [auth B].