› 8src

Electron Microscopy
2.92Å resolution

Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose

Released:
DOI: 10.2210/pdb8src/pdb
PDB entry 8src coloured by chain, front view.
PDB entry 8src coloured by chain, side view.
PDB entry 8src coloured by chain, top view.
Source organism: Salpingoeca rosetta
Primary publication:
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Huang Y, Kumar S, Lee J, Lü W, Du J
Nat Struct Mol Biol (2024)
PMID: 38773335
Related structures: EMD-40726

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nudix hydrolase domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1494 amino acids
Theoretical weight: 168.25 KDa
Source organism: Salpingoeca rosetta
Expression system: Homo sapiens
UniProt:
  • Canonical: F2UB89 (Residues: 1-1494; Coverage: 100%)
Gene name: PTSG_05449
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand APR 8 x APR
Ligand CA 17 x CA
Ligand CLR 12 x CLR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.92Å
Relevant EMDB volumes: EMD-40726
Expression system: Homo sapiens

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