› 8srp

Electron Microscopy
3.7Å resolution

FoxP3 forms Ladder-like multimer to bridge TTTG repeats

Released:
DOI: 10.2210/pdb8srp/pdb
PDB entry 8srp coloured by chain, front view.
PDB entry 8srp coloured by chain, side view.
PDB entry 8srp coloured by chain, top view.
Source organisms:
Primary publication:
FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Zhang W, Leng F, Wang X, Ramirez RN, Park J, Benoist C, Hur S
Nature (2023)
PMID: 38030726
Related structures: EMD-40737

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-232363 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Forkhead box protein P3 41 kDa form Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 236 amino acids
Theoretical weight: 27.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99JB6 (Residues: 188-423; Coverage: 55%)
Gene name: Foxp3
Sequence domains:
DNA 72-mer Chains: L, N
Molecule details ›
Chains: L, N
Length: 72 nucleotides
Theoretical weight: 22.07 KDa
Source organism: synthetic construct
Expression system: Not provided
DNA 72-mer Chains: K, M
Molecule details ›
Chains: K, M
Length: 72 nucleotides
Theoretical weight: 22.31 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-40737
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 mention without citation

FOXP3 recognizes microsatellites and bridges DNA through multimerization.
Zhang et al. (2023)