› 8ss5

Electron Microscopy
3.56Å resolution

Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state)

Released:
DOI: 10.2210/pdb8ss5/pdb
PDB entry 8ss5 coloured by chain, front view.
PDB entry 8ss5 coloured by chain, side view.
PDB entry 8ss5 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar SP, Yen LY, Yelshanskaya MV, Korman A, Jones DR, Sobolevsky AI
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37653241
Related structures: EMD-40744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-228099 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2; Voltage-dependent calcium channel gamma-5 subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1026 amino acids
Theoretical weight: 114.98 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Canonical: Q8VHW8 (Residues: 4-207; Coverage: 74%)
Gene names: Cacng5, GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.56Å
Relevant EMDB volumes: EMD-40744
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Structural dynamics in α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor gating.
Gonzalez et al. (2024)
1 more

1 mention without citation

Modulation of GluA2-γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Gangwar et al. (2023)