› 8sur

Electron Microscopy
3.1Å resolution

TMEM16F bound with Niclosamide

Released:
DOI: 10.2210/pdb8sur/pdb
PDB entry 8sur coloured by chain, front view.
PDB entry 8sur coloured by chain, side view.
PDB entry 8sur coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
OpenAccess logo Nat Commun 14 4874 (2023)
PMID: 37573365
Related structures: EMD-40776

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Anoctamin-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 911 amino acids
Theoretical weight: 106.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P9J9 (Residues: 1-911; Coverage: 100%)
Gene names: Ano6, Tmem16f
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand CA 5 x CA
Ligand NAG 3 x NAG
Ligand VUT 1 x VUT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-40776
Expression system: Homo sapiens

Quick links

Citations

2 citation in other articles

Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine.
Ousingsawat et al. (2024)
1 more