› 8swf

Electron Microscopy
3.39Å resolution

Cryo-EM structure of NLRP3 open octamer

Released:
DOI: 10.2210/pdb8swf/pdb
PDB entry 8swf coloured by chain, front view.
PDB entry 8swf coloured by chain, side view.
PDB entry 8swf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of NLRP3 reveal its self-activation mechanism
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024)
Related structures: EMD-40811

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-275271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 3 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 910 amino acids
Theoretical weight: 103.68 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96P20 (Residues: 130-1036; Coverage: 88%)
Gene names: C1orf7, CIAS1, NALP3, NLRP3, PYPAF1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.39Å
Relevant EMDB volumes: EMD-40811
Expression system: Spodoptera frugiperda

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