› 8swz

X-ray diffraction
3Å resolution

PARP4 ART domain bound to EB47

Released:
DOI: 10.2210/pdb8swz/pdb
PDB entry 8swz coloured by chain, front view.
PDB entry 8swz coloured by chain, side view.
PDB entry 8swz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Frigon L, Pascal JM
OpenAccess logo Nucleic Acids Res (2023)
PMID: 37971310

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP4 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 259 amino acids
Theoretical weight: 28.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKK3 (Residues: 242-282, 365-573; Coverage: 15%)
Gene names: ADPRTL1, KIAA0177, PARP4, PARPL
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand UHB 2 x UHB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2221
Unit cell:
a: 116.848Å b: 150.859Å c: 104.613Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.248
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.
Frigon et al. (2023)