› 8t0a

X-ray diffraction
2.14Å resolution

Crystal structure of integrin beta-2 tail bound to the FERM-folded talin head domain with a Y270E mutation

Released:
DOI: 10.2210/pdb8t0a/pdb
PDB entry 8t0a coloured by chain, front view.
PDB entry 8t0a coloured by chain, side view.
PDB entry 8t0a coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Wu J, Gao T

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin beta-2; Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 411 amino acids
Theoretical weight: 47.37 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11835 (Residues: 750-759; Coverage: 1%)
  • Canonical: P26039 (Residues: 1-430; Coverage: 16%)
Gene names: Itgb2, Tln, Tln1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS-II BEAMLINE 17-ID-1
Unit cell:
a: 66.775Å b: 68.644Å c: 110.386Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.23
Expression system: Escherichia coli BL21(DE3)

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