› 8t0k

Electron Microscopy
3.58Å resolution

Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state

Released:
DOI: 10.2210/pdb8t0k/pdb
PDB entry 8t0k coloured by chain, front view.
PDB entry 8t0k coloured by chain, side view.
PDB entry 8t0k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission.
Jimah JR, Kundu N, Stanton AE, Sochacki KA, Canagarajah B, Chan L, Strub MP, Wang H, Taraska JW, Hinshaw JE
Dev Cell (2024)
PMID: 38663399
Related structures: EMD-40942

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-1 Chains: b, c, f, g
Molecule details ›
Chains: b, c, f, g
Length: 876 amino acids
Theoretical weight: 98.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05193 (Residues: 1-864; Coverage: 100%)
Gene names: DNM, DNM1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GDP 4 x GDP
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.58Å
Relevant EMDB volumes: EMD-40942
Expression system: Homo sapiens

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