› 8t2h

X-ray diffraction
1.85Å resolution

DYRK1A complex with DYR530

Released:
DOI: 10.2210/pdb8t2h/pdb
PDB entry 8t2h coloured by chain, front view.
PDB entry 8t2h coloured by chain, side view.
PDB entry 8t2h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Montfort WR, Basantes LE

Function and Biology Details

Reactions catalysed: 
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Chains: A, B
Molecule details ›
Chains: A, B
Length: 365 amino acids
Theoretical weight: 42.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13627 (Residues: 126-490; Coverage: 48%)
Gene names: DYRK, DYRK1A, MNB, MNBH
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand XIR 2 x XIR
Ligand PG4 1 x PG4
Ligand GOL 3 x GOL
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER METALJET
Spacegroup: P212121
Unit cell:
a: 63.472Å b: 83.213Å c: 146.675Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.163 0.213
Expression system: Escherichia coli

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