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Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids

Source organism: Homo sapiens
Biochemical function: fibrinogen binding
Biological process: cell adhesion mediated by integrin
Cellular component: integrin alphaIIb-beta3 complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01839
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-IIb
The deposited structure of PDB entry 8t2v contains 2 copies of Pfam domain PF01839 (FG-GAP repeat) in Integrin alpha-IIb. Showing 2 copies in chain A.

PF08725
Domain description: Integrin beta cytoplasmic domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF08725 (Integrin beta cytoplasmic domain) in Integrin beta-3. Showing 1 copy in chain B.

PF07965
Domain description: Integrin beta tail domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF07965 (Integrin beta tail domain) in Integrin beta-3. Showing 1 copy in chain B.

PF07974
Domain description: EGF-like domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF07974 (EGF-like domain) in Integrin beta-3. Showing 1 copy in chain B.

PF18372
Domain description: Integrin beta epidermal growth factor like domain 1
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF18372 (Integrin beta epidermal growth factor like domain 1) in Integrin beta-3. Showing 1 copy in chain B.

PF00362
Domain description: Integrin beta chain VWA domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF00362 (Integrin beta chain VWA domain) in Integrin beta-3. Showing 1 copy in chain B.

PF17205
Domain description: Integrin plexin domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF17205 (Integrin plexin domain) in Integrin beta-3. Showing 1 copy in chain B.

PF00357
Domain description: Integrin alpha cytoplasmic region
Occurring in:
  1. Integrin alpha-IIb
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF00357 (Integrin alpha cytoplasmic region) in Integrin alpha-IIb. Showing 1 copy in chain A.

PF20806
Domain description: Integrin alpha Ig-like domain 3
Occurring in:
  1. Integrin alpha-IIb
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF20806 (Integrin alpha Ig-like domain 3) in Integrin alpha-IIb. Showing 1 copy in chain A.

PF20805
Domain description: Integrin alpha Ig-like domain 2
Occurring in:
  1. Integrin alpha-IIb
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF20805 (Integrin alpha Ig-like domain 2) in Integrin alpha-IIb. Showing 1 copy in chain A.

PF08441
Domain description: Integrin alpha Ig-like domain 1
Occurring in:
  1. Integrin alpha-IIb
The deposited structure of PDB entry 8t2v contains 1 copy of Pfam domain PF08441 (Integrin alpha Ig-like domain 1) in Integrin alpha-IIb. Showing 1 copy in chain A.

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