› 8t3l

Electron Microscopy
3.6Å resolution

TRPV1 in nanodisc bound with 2 LPA molecules in neighboring monomers

Released:
DOI: 10.2210/pdb8t3l/pdb
PDB entry 8t3l coloured by chain, front view.
PDB entry 8t3l coloured by chain, side view.
PDB entry 8t3l coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y
Nat Struct Mol Biol (2024)
PMID: 38698206
Related structures: EMD-41005

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 637 amino acids
Theoretical weight: 73.02 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 110-764; Coverage: 75%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 8IJ 2 x 8IJ
Ligand NA 2 x NA
Ligand NKN 2 x NKN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-41005
Expression system: Homo sapiens

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