› 8t4j

Electron Microscopy
3.9Å resolution

Transporter associated with antigen processing (TAP) bound to the 14-mer peptide LPAVVGLSPGEQEY

Released:
DOI: 10.2210/pdb8t4j/pdb
PDB entry 8t4j coloured by chain, front view.
PDB entry 8t4j coloured by chain, side view.
PDB entry 8t4j coloured by chain, top view.
Source organisms:
Entry authors: Lee J, Oldham ML, Chen J
Related structures: EMD-41033

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + antigen peptide(Side 1) = ADP + phosphate + antigen peptide(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-246075 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antigen peptide transporter 2 Chain: B
Molecule details ›
Chain: B
Length: 686 amino acids
Theoretical weight: 75.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03519 (Residues: 1-686; Coverage: 100%)
Gene names: ABCB3, PSF2, RING11, TAP2, Y1
Sequence domains:
Antigen peptide transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 748 amino acids
Theoretical weight: 81.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q03518 (Residues: 1-748; Coverage: 100%)
Gene names: ABCB2, PSF1, RING4, TAP1, Y3
Sequence domains:
HLA-B35 specific peptide Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.46 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-41033
Expression systems:
  • Homo sapiens
  • Not provided

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