› 8t50

Electron Microscopy
3.6Å resolution

Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL

Released:
DOI: 10.2210/pdb8t50/pdb
PDB entry 8t50 coloured by chain, front view.
PDB entry 8t50 coloured by chain, side view.
PDB entry 8t50 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B
OpenAccess logo Nat Commun 15 5216 (2024)
PMID: 38890331
Related structures: EMD-41041

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 890 amino acids
Theoretical weight: 98.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 100%)
Gene names: BCNG1, HCN1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CMP 4 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-41041
Expression system: Homo sapiens

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Citations

1 review citation

Artificial Intelligence in Medical Affairs: A New Paradigm with Novel Opportunities.
Fröling et al. (2024)
2 other articles