› 8t51

X-ray diffraction
1.9Å resolution

Crystal structure of Fab 3.10C2 bound to TREM2

Released:
DOI: 10.2210/pdb8t51/pdb
PDB entry 8t51 coloured by chain, front view.
PDB entry 8t51 coloured by chain, side view.
PDB entry 8t51 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hsu PL, Wallweber H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246133 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
3.10C2 Fab heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 222 amino acids
Theoretical weight: 23.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3.10C2 Fab light chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 219 amino acids
Theoretical weight: 23.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Triggering receptor expressed on myeloid cells 2 Chains: E, F
Molecule details ›
Chains: E, F
Length: 20 amino acids
Theoretical weight: 2.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NZC2 (Residues: 148-164, 165-166; Coverage: 9%)
Gene name: TREM2

Ligands and Environments

5 bound ligands:
Ligand SO4 8 x SO4
Ligand ZN 8 x ZN
Ligand GOL 9 x GOL
Ligand ACT 5 x ACT
Ligand PEG 4 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Unit cell:
a: 66.38Å b: 96.029Å c: 144.316Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.24
Expression systems:
  • Homo sapiens
  • Not provided

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