› 8t6f

X-ray diffraction
1.56Å resolution

Crystal structure of human MBP-Myeloid cell leukemia 1 (Mcl-1) in complex with BRD810 inhibitor

Released:
DOI: 10.2210/pdb8t6f/pdb
PDB entry 8t6f coloured by chain, front view.
PDB entry 8t6f coloured by chain, side view.
PDB entry 8t6f coloured by chain, top view.
Source organisms:
Entry authors: Poncet-Montange G, Lemke CT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 57.31 KDa
Source organisms: Expression system: Escherichia coli O157:H7
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: Q07820 (Residues: 174-321; Coverage: 42%)
Gene names: BCL2L3, JW3994, MCL1, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
4 bound ligands:
Ligand MG 1 x MG
Ligand YI7 1 x YI7
Ligand DMS 1 x DMS
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P21212
Unit cell:
a: 98.301Å b: 136.957Å c: 38.257Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.218
Expression system: Escherichia coli O157:H7

Quick links