› 8t6j

Electron Microscopy
3.5Å resolution

CDPPB-bound inactive mGlu5

Released:
DOI: 10.2210/pdb8t6j/pdb
PDB entry 8t6j coloured by chain, front view.
PDB entry 8t6j coloured by chain, side view.
PDB entry 8t6j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Stepwise activation of a metabotropic glutamate receptor.
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK
Nature (2024)
PMID: 38632403
Related structures: EMD-41069

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 881 amino acids
Theoretical weight: 98.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41594 (Residues: 20-876; Coverage: 72%)
Gene names: GPRC1E, GRM5, MGLUR5
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand YKU 2 x YKU
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-41069
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Step-wise activation of a Family C GPCR.
Kumar et al. (2023)