› 8t6u

Electron Microscopy
3.13Å resolution

Cryo-EM structure of human Anion Exchanger 1 bound to Dipyridamole

Released:
DOI: 10.2210/pdb8t6u/pdb
PDB entry 8t6u coloured by chain, front view.
PDB entry 8t6u coloured by chain, side view.
PDB entry 8t6u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Substrate binding and inhibition of the anion exchanger 1 transporter.
Capper MJ, Yang S, Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Zhao Y, Schlessinger A, Mezei M, Osman R, Zhang B, Wacker D
Nat Struct Mol Biol (2023)
PMID: 37679563
Related structures: EMD-41081

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136111 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Band 3 anion transport protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 523 amino acids
Theoretical weight: 58.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P02730 (Residues: 369-891; Coverage: 57%)
Gene names: AE1, DI, EPB3, SLC4A1
Sequence domains: HCO3- transporter integral membrane domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand CLR 8 x CLR
Ligand PC1 2 x PC1
Ligand H9F 2 x H9F
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.13Å
Relevant EMDB volumes: EMD-41081
Expression system: Spodoptera frugiperda

Quick links

Citations

1 citations in other articles

Mechanism of anion exchange and small-molecule inhibition of pendrin.
Wang et al. (2024)