› 8t84

X-ray diffraction
1.1Å resolution

Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes hexafluoroisopropanol

Released:
DOI: 10.2210/pdb8t84/pdb
PDB entry 8t84 coloured by chain, front view.
PDB entry 8t84 coloured by chain, side view.
PDB entry 8t84 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Racemic Peptides from Amyloid β and Amylin Form Rippled β-Sheets Rather Than Pleated β-Sheets.
Hazari A, Sawaya MR, Sajimon M, Vlahakis N, Rodriguez J, Eisenberg D, Raskatov JA
J Am Chem Soc (2023)
PMID: 37972334

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Racemic mixture of amyloid beta segment 35-MVGGVV-40 Chain: AAA
Molecule details ›
Chain: AAA
Length: 6 amino acids
Theoretical weight: 561 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CFH 2 x CFH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Unit cell:
a: 9.42Å b: 11.22Å c: 21.12Å
α: 96.565° β: 89.572° γ: 94.951°
R-values:
R R work R free
0.19 0.189 0.204
Expression system: Not provided

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