› 8t8z

X-ray diffraction
2.6Å resolution

Crystal structure of Terrestrivirus Inositol pyrophosphatase kinase in complex with ADP and myo-(1OH)IP5

Released:
DOI: 10.2210/pdb8t8z/pdb
PDB entry 8t8z coloured by chain, front view.
PDB entry 8t8z coloured by chain, side view.
PDB entry 8t8z coloured by chain, top view.
Source organism: Terrestrivirus sp.
Primary publication:
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus.
Zong G, Desfougères Y, Portela-Torres P, Kwon YU, Saiardi A, Shears SB, Wang H
EMBO J (2024)
PMID: 38216735

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-497442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinase Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.69 KDa
Source organism: Terrestrivirus sp.
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A3G4ZNY6 (Residues: 17-265; Coverage: 94%)
Gene name: Terrestrivirus9_15
Sequence domains: Inositol polyphosphate kinase

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand ZNU 1 x ZNU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 63.841Å b: 103.835Å c: 102.719Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.174 0.235
Expression system: Escherichia coli

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