› 8ta2

Electron Microscopy
2.74Å resolution

Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42

Released:
DOI: 10.2210/pdb8ta2/pdb
PDB entry 8ta2 coloured by chain, front view.
PDB entry 8ta2 coloured by chain, side view.
PDB entry 8ta2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Xu M, Neelands T, Powers AS, Liu Y, Miller SD, Pintilie GD, Bois JD, Dror RO, Chiu W, Maduke M
Elife 12 (2024)
PMID: 38345841
Related structures: EMD-41126

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 479 amino acids
Theoretical weight: 52.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51788 (Residues: 88-566; Coverage: 53%)
Gene name: CLCN2
Sequence domains: Voltage gated chloride channel

Ligands and Environments

2 bound ligands:
Ligand GH6 2 x GH6
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.74Å
Relevant EMDB volumes: EMD-41126
Expression system: Homo sapiens

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