› 8tbb

X-ray diffraction
2.5Å resolution

F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3

Released:
DOI: 10.2210/pdb8tbb/pdb
PDB entry 8tbb coloured by chain, front view.
PDB entry 8tbb coloured by chain, side view.
PDB entry 8tbb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Oganesyan V, van Dyk N, Mazor Y, Yang C

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250833 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hepatitis A virus cellular receptor 2 Chain: D
Molecule details ›
Chain: D
Length: 110 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TDQ0 (Residues: 22-131; Coverage: 39%)
Gene names: HAVCR2, TIM3, TIMD3
Sequence domains: Immunoglobulin V-set domain
F9S Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
F9S Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P21
Unit cell:
a: 72.805Å b: 57.005Å c: 80.453Å
α: 90° β: 106° γ: 90°
R-values:
R R work R free
0.194 0.191 0.241
Expression systems:
  • Homo sapiens
  • Cricetulus griseus

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