› 8tbx

X-ray diffraction
2.71Å resolution

Crystal structure of human DDX1 helicase in complex with ADP

Released:
DOI: 10.2210/pdb8tbx/pdb
PDB entry 8tbx coloured by chain, front view.
PDB entry 8tbx coloured by chain, side view.
PDB entry 8tbx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zeng H, Dong A, Li Y, Yen H, Hejazi Z, Seitova A, Arrowsmith CH, Edwards AM, Halabelian L

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187668 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent RNA helicase DDX1 Chain: A
Molecule details ›
Chain: A
Length: 470 amino acids
Theoretical weight: 52.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92499 (Residues: 1-74, 286-674; Coverage: 63%)
  • Best match: Q92499-3 (Residues: 158-546)
Gene name: DDX1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 50.708Å b: 71.517Å c: 138.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.203 0.286
Expression system: Spodoptera frugiperda

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