› 8tdu

X-ray diffraction
3.11Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151133 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chains: A, C
Molecule details ›
Chains: A, C
Length: 1068 amino acids
Theoretical weight: 124.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42336 (Residues: 1-1068; Coverage: 100%)
Gene name: PIK3CA
Sequence domains:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chains: B, D
Molecule details ›
Chains: B, D
Length: 293 amino acids
Theoretical weight: 35.2 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P27986 (Residues: 308-593; Coverage: 40%)
Gene names: GRB1, PIK3R1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand X3N 2 x X3N
Ligand ZWE 2 x ZWE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: P21
Unit cell:
a: 86.34Å b: 124.72Å c: 165.84Å
α: 90° β: 92.8° γ: 90°
R-values:
R R work R free
0.211 0.208 0.267
Expression system: Trichoplusia ni

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