› 8tf4

Electron Microscopy
2.86Å resolution

Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole

Released:
DOI: 10.2210/pdb8tf4/pdb
PDB entry 8tf4 coloured by chain, front view.
PDB entry 8tf4 coloured by chain, side view.
PDB entry 8tf4 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural mechanism of TRPV5 inhibition by econazole.
De Jesús-Pérez JJ, Gabrielle M, Raheem S, Fluck EC, Rohacs T, Moiseenkova-Bell VY
Structure (2023)
PMID: 38141613
Related structures: EMD-41219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 739 amino acids
Theoretical weight: 83.78 KDa
Source organism: Oryctolagus cuniculus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9XSM3 (Residues: 1-730; Coverage: 100%)
Gene names: Ecac1, Trpv5
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ERG 8 x ERG
Ligand CPL 8 x CPL
Ligand ECN 4 x ECN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.86Å
Relevant EMDB volumes: EMD-41219
Expression system: Saccharomyces cerevisiae

Quick links