› 8tga

Electron Microscopy
3.65Å resolution

Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound

Released:
DOI: 10.2210/pdb8tga/pdb
PDB entry 8tga coloured by chain, front view.
PDB entry 8tga coloured by chain, side view.
PDB entry 8tga coloured by chain, top view.
Source organisms:
Entry authors: Franklin MC, Romero Hernandez A
Related structures: EMD-41234

Function and Biology Details

Reaction catalysed: 
GTP = 3',5'-cyclic GMP + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-247159 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Atrial natriuretic peptide receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 469 amino acids
Theoretical weight: 52.26 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16066 (Residues: 33-473; Coverage: 43%)
Gene names: ANPRA, NPR1
Sequence domains: Receptor family ligand binding region
REGN5381 Fab light chain Chains: F, L
Molecule details ›
Chains: F, L
Length: 213 amino acids
Theoretical weight: 23.32 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
REGN5381 Fab heavy chain Chains: E, H
Molecule details ›
Chains: E, H
Length: 229 amino acids
Theoretical weight: 24.82 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.65Å
Relevant EMDB volumes: EMD-41234
Expression system: Cricetulus griseus

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