› 8tgi

Electron Microscopy
3.4Å resolution

VMAT1 dimer with dopamine and reserpine

Released:
DOI: 10.2210/pdb8tgi/pdb
PDB entry 8tgi coloured by chain, front view.
PDB entry 8tgi coloured by chain, side view.
PDB entry 8tgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into vesicular monoamine storage and drug interactions.
Ye J, Chen H, Wang K, Wang Y, Ammerman A, Awasthi S, Xu J, Liu B, Li W
Nature (2024)
PMID: 38499039
Related structures: EMD-41237

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromaffin granule amine transporter Chains: A, B
Molecule details ›
Chains: A, B
Length: 470 amino acids
Theoretical weight: 50.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P54219 (Residues: 1-525; Coverage: 90%)
Gene names: SLC18A1, VAT1, VMAT1
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

2 bound ligands:
Ligand LDP 1 x LDP
Ligand YHR 1 x YHR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-41237
Expression system: Komagataella pastoris

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