› 8thr

Electron Microscopy
3.12Å resolution

Structure of the human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine in an occluded conformation

Released:
DOI: 10.2210/pdb8thr/pdb
PDB entry 8thr coloured by chain, front view.
PDB entry 8thr coloured by chain, side view.
PDB entry 8thr coloured by chain, top view.
Source organism: Aequorea victoria
Primary publication:
Structural mechanisms for VMAT2 inhibition by tetrabenazine.
Dalton MP, Cheng MH, Bahar I, Coleman JA
OpenAccess logo Elife 12 (2024)
PMID: 38517752
Related structures: EMD-41269

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptic vesicular amine transporter Chain: A
Molecule details ›
Chain: A
Length: 858 amino acids
Theoretical weight: 93.85 KDa
Source organism: Aequorea victoria
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05940 (Residues: 12-483; Coverage: 92%)
Gene names: SLC18A2, SVMT, VMAT2
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

1 bound ligand:
Ligand EBZ 1 x EBZ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-41269
Expression system: Homo sapiens

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